Only Murders in the Building Guest Stars: Renée Zellweger, Christoph Waltz Among Best Only Murders in the Building has featured standout guest stars like Renée Zellweger and Christoph Waltz. As season 6 heads to London, we look back at the best. For the past five years, Only Murders in the Building has brought to life many interesting characters who have left their mark on the acclaimed show. Each season, Hulu’s murder-mystery series consistently delivers masterclass acting, elevated by the stellar chemistry of Steve Martin, Selena Gomez, and Martin Short. Gomez’s deadpan humor matches Short's and Martin’s double act, refined by their decades-long creative partnership. The oddball trio’s chemistry lets them shine individually without overshadowing one another. While the leading trio remains the emotional anchor of Only Murders in the Building, the show’s revolving cast of guest stars makes each season thrilling and refreshing. This clever format keeps the hit Hulu series from falling into formulaic repetition, a common issue for traditional comedy shows.Throughout its run, fans have seen a slew of outstanding guest stars, who portrayed eccentric characters with bonkers storylines. With the level of talent joining Martin, Gomez, and Short in every installment, it's no surprise it remains one of Hulu's best shows. From Glee alum Jane Lynch to Oscar winner Renée Zellweger, Only Murders in the Building's incredible roster of celebrity cameos and guest stars has raised the quality of the whodunit genre, transforming the acclaimed series into a cinematic spectacle.Ahead of the new wave of A-listers joining Only Murders in London, which premieres on December 8, 2026, let's look back on the guest stars who made the most impact during the show's first five seasons.Renée Zellweger and Christoph Waltz in Season 5Renée Zellweger played Camila White in Only Murders in the Building season 5, one of the prime suspects in the fifth season’s murder mystery involving the death of Arconia doorman Lester. The Oscar winner showed off her comedic chops, playing a highly competitive billionaire who wants to turn the Arconia into the city’s first luxury casino. Zellweger delivered a fun, hilarious performance inspired by real-life wellness and lifestyle gurus obsessed with aesthetics and home decor.Even though Camila wasn't the real killer, Only Murders in the Building season 5, episode 8, Cuckoo Chicks, proved she's one of the show's most interesting villains. Her elegant appearance effectively masked her criminal activities and manipulative side, making her the unlikely leader of the wicked billionaire trio.Like Zellweger, Christoph Waltz also played an antagonist in Only Murders in the Building season 5. He was introduced as Bash Steed, an eccentric tech billionaire obsessed with achieving immortality. This isn’t Waltz’s first time portraying oddball villains, thanks to his iconic roles in 2009’s Inglourious Basterds and 2015’s Spectre. Critics and fans praised the character, entertained by his absurd jokes and comedic timing. Unlike his previous intense roles, Bash Steed stands out because of how uniquely whimsical the character is. Bash’s menacing aura is outweighed by his unintentional ridiculousness, which makes his scenes with the leading trio so fun to watch.Nathan Lane and Tina Fey: Early Fan FavoritesNathan Lane joined the first two seasons of Only Murders in the Building as the charming Teddy Dimas, introduced as Oliver’s longtime friend and one of the Arconia’s wealthy residents. Along with his Deaf son Theo, Teddy was one of Mabel, Charles, and Oliver’s prime suspects in the death of Tim Kono in season 1. During their investigation, it was revealed that Teddy was the criminal mastermind behind an illegal jewelry-selling ring, which involved him stealing expensive jewelry from the Arconia’s deceased residents. In his portrayal of Teddy Dimas, Lane wasn’t only a comedic marvel but also showcased his character’s emotional depth and complex relationship with Theo. Lane's performance in season 1’s dialogue-free seventh episode, The Boy from 6B, earned him an Emmy Award for Outstanding Guest Actor.Tina Fey’s Cinda Canning has been a delightful part of Only Murders in the Building since season 1. She was introduced as a popular true-crime podcast host who inspired Charles, Oliver, and Mabel to do one on their own. Fey brilliantly portrayed Cinda’s ruthlessness and insincerity through her signature satirical style of comedy. The idol-turned-rival's shocking appearance in Only Murders in the Building's season 5 finale is a full-circle moment. After being absent from the main storylines of the last two seasons, Tina Fey's Cinda Canning takes center stage in Only Murders in the Building season 6. Her unexpected death leads Mabel, Charles, and Oliver to London, where Cinda was investigating the case of a young woman accused of murder.Jane Lynch and the Upcoming London SeasonJane Lynch’s portrayal of Sazz Pataki has been one of the best recurring parts of Only Murders in the Building. Sazz was Charles’ long-time friend and unlikely stunt double, who hilariously mimicked Charles’ look and physicality on and off-screen. Her performance brought warmth and humor to the show, making her a fan favorite across multiple seasons.The series continues to attract top-tier talent, and the upcoming season set in London promises even more star power. As the show evolves, the guest stars remain a key ingredient in its success, keeping audiences engaged with fresh mysteries and unforgettable characters. With season 6 on the horizon, fans can expect more surprises and standout performances from the ever-expanding roster of celebrities.