The San Francisco 49ers face significant roster uncertainty heading into Sunday's matchup against the Denver Broncos. several key players, including wide receiver Mike Evans and linebacker Dre Greenlaw,are currently listed as questionable on the team's final injury report.

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Mike Evans' battle with broken ribs from a July car crash

The 49ers' offensive rhythm faces a major threat as wide receiver Mike Evans deals with the lingering effects of a July car accident. According to the team's injury report, Evans is listed as questionable for Sunday's game against the Denver Broncos due to broken ribs. This injury is particularly concerning because Evans, 32, had to leave a previous game on a cart after experiencing intense pain. While Evans has a history of pushing through hamstring issues, fractured ribs represent a more significant physical hurdle.

Coach Kyle Shanahan noted that the pain is something he understands personally, having suffered three broken ribs and a concussion in a similar two-car collision this past July. While Shanahan expressed confidence in Evans' toughness, General Manager John Lynch told KNBR 680-AM that the organization will prioritize the player's long-term health over immediate availability.

The defensive void left by Nick Bosa and Mykel Williams

The San Francisco 49ers' defensive front will be significantly weakened for the upcoming contest. Defensive end Nick Bosa has been ruled out for Sunday due to a calf strain on his right leg, an injury complicating his recovery from a previous ACL repair. Additionally, defensive end Mykel Williams is also out as he serves a mandatory four-game period on the Physically Unable to Perform list.

The loss of these two players, combined with defensive tackle James Thompson Jr. being out with a high-ankle sprain, places immense pressure on the remaining defensive rotation. There is also a lingering question regarding Bosa's recovery timeline; the team must consider whether traveling to Seattle for the October 11 game could delay his return by another week.

Linebacker concerns for Dre Greenlaw and Jaden Dugger

Beyond the defensive line, the 49ers are facing uncertainty in their linebacker corps. Linebacker Dre Greenlaw is listed as questionable following a quad contusion that sidelined him during last week's action. Adding to this instability , rookie Jaden Dugger is also a game-time decision after sustaining a shoulder injury during Thursday's practice session.

The potential absence of both Greenlaw and Dugger creates a precarious situation for San Francisco's defensive schemes as they prepare for Denver. If both players are unable to suit up, the 49ers may be forced to rely on depth players who have yet to prove they can handle the workload of a high-stakes NFL game.

A silver lining in Trent Williams' full availability

Despite the mounting list of injuries, there is a notable positive for the San Francisco 49ers' offensive line. All-Pro left tackle Trent Williams appears to have escaped the worst of his recent physical setbacks. Although he missed Wednesday's practice following a neck stinger in the previous game, Williams returned to the field on Thursday.

The team expects Williams to be fully available for the matchup against the Denver Broncos. his presence provides a much-needed stabilizer for an offense that is currently navigating a wave of injuries to key skill players and defensive anchors.

Dante Pettis and the question of 49ers roster depth

The impact of recent injuries extends to the practice squad, where wide receiver Dante Pettis injured his calf during his first practice since signing with the team. This leaves several unanswered questions for the 49ers' coaching staff regarding their depth. It remains unclear how the team will adjust their defensive rotation to cover the gaps left by Bosa and Williams, and the organization has not yet confirmed if Pettis will be able to contribute in any capacity following his injury.