Ellen Pompeo, best known as Meredith Grey on ABC's long-running medical drama Grey's Anatomy, is returning to television in a new crime-comedy series titled Chicks alongside X-Files actress Annabeth Gish.. According to the report,the show is set in the rapidly gentrifying neighborhoods of old Boston and follows two half-sisters who inherit their father's “two-bit crime” and run increasingly audacious frauds.

‘Chicks’: A Boston crime-comedy built on Pompeo's hometown roots

The series was inspired by conversations between Pompeo and the producer, and taps into her Massachusetts roots—Pompeo was born in Everett,Massachusetts.. The show, which is planned to begin filming in September in New York, will be executive produced by Pompeo, according to the report. Chicks marks her first regular TV role since stepping down as a series regular on Grey's Anatomy in 2023.

Annabeth Gish co-stars as one half of a sister act running audacious frauds

Annabeth Gish, known for The X-Files, joins Pompeo in the lead roles. The story centers on half-sisters who inherit their father's small-time criminal enterprise and escalate to elaborate scams, bonding over their financial struggles. The setting of gentrifying Boston adds a layer of socioeconomic commentary, the report says.

A rural West Texas spinoff keeps Pompeo in the Grey's Anatomy franchise

While Pompeo exited as a series regular in 2023, she remains deeply involved with the Grey's Anatomy universe. ABC has ordered a spiinoff set in rural West Texas, with Pompeo serving as executive producer, the report states. Additionally,she is expected to return as Meredith Grey as a recurring character for the next three to five seasons. Grey's Anatomy itself is set to return for season 23.

Pompeo's 2023 exit and the three-to-five season recurrence plan

After confirming her exit from the series regular role in 2023, Pompeo hinted that she would return for multiple appearances across future seasons. The source reports that she will recur for three to five seasons, meaning viewers can expect Meredith Grey to appear intermittently as the show continues. The medical drama has faced significant cast shake-ups this season, but ABC remains committed to the franchise.

Unconfirmed details: The 'Chicks' preiere date and West Texas spinoff cast

As of now, no premiere date for Chicks has been announced beyond the September production start. The West Texas spinoff also lacks a confirmed cast and showrunner. The source notes that more details on Pompeo's return will be available next week, leaving fans waiting for concrete timelines and additional casting news. It remains unclear whether any original cast members from Grey's Anatomy will join the spinoff.